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Thesis work description: Join our research team to investigate how obesity affects pharmacokinetics and pharmacodynamics in a preclinical context, and how these findings can be useful in a translational setting. This master thesis project addresses interesting aspects of how obesity and related comorbidities may influence drug absorption, distribution, metabolism and excretion (ADME) processes and drug efficacy across different drug modalities. The project will utilize advanced PK/PD modeling and simulation (M&S), working with both internal and external data sets, to support improved translation from preclinical to clinical applications. Impact: This project will harness advanced PK/PD M&S to understand how obesity and its associated comorbidities could affect ADME and drug efficacy. Key Objectives: Apply PK/PD M&S to analyze and interpret preclinical and clinical data Study the influence of obesity on the pharmacokinetics and pharmacodynamic parameters of various drug modalities Deepen understanding of how obesity and related comorbidities modulate ADME processes and drug efficacy Support translation of research findings into potential clinical impact. Location: This is an on-site position requiring a minimum of three days per week in the office at AstraZeneca Gothenburg. AstraZeneca does not support with relocation/accommodation. 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